Schopenhauer maintained that pleasure leaves neither trace nor memory. After a pleasant sensation there is only the anxiety to get more of the same or the boredom of not achieving it.

Pain accompanies desire and failure, the absence and imminence of mourning after love or after the greatest of glories. Pain ends up being the very skin of life. The pain lasts. Michael J. Fox says his Parkinson's is "getting harder" and he can't imagine "living like this until I'm 80"