Until 1953 the heart was practically uncharted territory. American doctor John H.

Gibbon had been working for years on the idea of a machine that would do the functions of the heart. On May 6, 1953, at Jefferson University Medical Center in Philadelphia, he used his heart-lung machine to shut down an atrial septal defect in an 18-year-old patient. From blind surgery to open heart surgery, which caused an exponential growth to go from nothing to everything.